Endosome maturation
نویسندگان
چکیده
منابع مشابه
Endosome maturation.
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies. The maturation programme entails a dramatic...
متن کاملArguments in favour of endosome maturation.
42. Draper. R. K. and Simon. M. I. (1980) J. Cell Biol. 87. 849-854 Pelham, H. R. B., Roberts, I,. M. and Lord, J. M. (1 992) Trends Cell Biol. 2, 183185 Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S. and Klausner, R. D. (1 989) Cell 56,801 -8 13 Misumi, Y., Miki, K., Takatsuki, A,, Tamura, G. and Ikehara, Y. (1986) J. Biol. Chem. 261, 11398-1 1403 Shite. S., Seguchi, T., Shimada, T., ...
متن کاملCullin-3 regulates late endosome maturation.
Cullin-3 (Cul3) functions as a scaffolding protein in the Bric-a-brac, Tramtrack, Broad-complex (BTB)-Cul3-Rbx1 ubiquitin E3 ligase complex. Here, we report a previously undescribed role for Cul3 complexes in late endosome (LE) maturation. RNAi-mediated depletion of Cul3 results in a trafficking defect of two cargoes of the endolysosomal pathway, influenza A virus (IAV) and epidermal growth fac...
متن کاملA new Rab7 effector controls phosphoinositide conversion in endosome maturation
Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth ...
متن کاملRubicon controls endosome maturation as a Rab7 effector.
The activation and recruitment of the small GTPase Rab7 to early endosome is a critical step for early to late endosome maturation, a process that requires the class III phosphatidylinositol 3-kinase (PI3KC3) and GTPase regulators. However, the molecular mechanism underlying Rab7 activation and endosome maturation is still poorly defined. Here we report that Rubicon, a component of the PI3KC3 c...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.286